Artemisinin and its derivatives belong to a family of drugs approved for the treatment of malaria with known clinical safety and efficacy. In addition to its anti-malarial effect, artemisinin displays anti-viral, anti-inflammatory, and anti-cancer effects in vivo and in vitro. Recently, much attention has been paid to the therapeutic role of artemisinin in liver diseases. Several studies suggest that artemisinin and its derivatives can protect the liver through different mechanisms, such as those pertaining to inflammation, proliferation, invasion, metastasis, and induction of apoptosis and autophagy. In this review, we provide a comprehensive discussion of the underlying molecular mechanisms and signaling pathways of artemisinin and its derivatives in treating liver diseases. Further pharmacological research will aid in determining whether artemisinin and its derivatives may serve as promising medicines for the treatment of liver diseases in the future.
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Individual plasma concentration–time curves of artemisinin in 15
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Artemisinin Based Nanomedicine for Therapeutic Applications: Recent Advances and Challenges - ScienceDirect
Chemical and spectroscopic characterization of (Artemisinin/Querctin/ Zinc) novel mixed ligand complex with assessment of its potent high antiviral activity against SARS-CoV-2 and antioxidant capacity against toxicity induced by acrylamide in male rats [
Artemisinin anti-malarial drugs in China - ScienceDirect
Enhancing the antimalarial activity of artesunate
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El-Megharbel: Chemical and spectroscopic characterization of (Artemisinin/Quercetin/ Zinc) novel mixed ligand complex with assessment of its potent high antiviral activity against SARS-CoV-2 and antioxidant capacity against toxicity induced by
Artemisia for Malaria By Dr. Eric Yarnell
Is structural hybridization invoking new dimensions for antimalarial drug discovery research? - RSC Medicinal Chemistry (RSC Publishing) DOI:10.1039/D3MD00083D
PDF) Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives
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Anti-malarial drug: the emerging role of artemisinin and its derivatives in liver disease treatment, Chinese Medicine
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
