The nature and cellular sources of NGAL, its biological role and diagnostic ability in AKI and the increasing concerns surrounding its diagnostic and clinical value are described. For many years, neutrophil gelatinase-associated lipocalin (NGAL) has been considered the most promising biomarker of acute kidney injury (AKI). Commercial assays and point-of-care instruments, now available in many hospitals, allow rapid NGAL measurements intended to guide the clinician in the management of patients with or at risk of AKI. However, these assays likely measure a mixture of different NGAL forms originating from different tissues. Systemic inflammation, commonly seen in critically ill patients, and several comorbidities contribute to the release of NGAL from haematopoietic and non-haematopoietic cells. The unpredictable release and complex nature of the molecule and the inability to specifically measure NGAL released by tubular cells have hampered its use a specific marker of AKI in heterogeneous critically ill populations. In this review, we describe the nature and cellular sources of NGAL, its biological role and diagnostic ability in AKI and the increasing concerns surrounding its diagnostic and clinical value.
Acute Kidney Injury Archives - Randox Laboratories
Acute kidney injury in pediatrics: an overview focusing on pathophysiology
Impact of clinical context on acute kidney injury biomarker performances: differences between neutrophil gelatinase-associated lipocalin and L-type fatty acid-binding protein
Longitudinal NGAL and cystatin C plasma profiles present a high level of heterogeneity in a mixed ICU population, BMC Nephrology
Neutrophil gelatinase-associated lipocalin: a promising biomarker
Acute Kidney Injury
High levels of cell-free DNA accurately predict late acute kidney injury in patients after cardiac surgery
Regulated necrosis and failed repair in cisplatin-induced chronic
Biomarkers in acute kidney injury: Evidence or paradigm? - ScienceDirect
Neutrophil gelatinase-associated lipocalin does not originate from
Conceptual advances and evolving terminology in acute kidney