The slip surface is an important control structure surface existing in the landslide. It not only directly affects the stability of the slope through the strength, but also affects the stress field by affecting the propagation of the stress wave. Many research results have been made on the influence of non-continuous stress wave propagation in rock and soil mass and the dynamic response to seismic slopes. However, the effect of the continuity of the slip surface on the slope dynamic stability needs further researches. Therefore, in this paper, the effect of slip surface on the slope’s instantaneous safety factor is analyzed by the theoretical method with the infinite slope model. Firstly, three types of slip surface model were established, to realize the change of sliding surface continuity in the infinite slope. Then, based on wave field analysis, the instantaneous safety factor was used to analyze the effect of continuity of slip surface. The results show that with the decreasing of slip surface continuity, the safety factor does not simply increase or decrease, and is related to slope features, incident wave and continuity of slip surface. The safety factor does not decrease monotonically with the increasing of slope angle and thickness of slope body. Moreover, the reflection of slope surface has a great influence on the instantaneous safety factor of the slope. Research results in this paper can provide some references to evaluate the stability of seismic slope, and have an initial understanding of the influence of structural surface continuity on seismic slope engineering.