Cursed since childhood, dentist Charlie Kagan (Dane Cook) cannot find the right woman. Even worse, he learns that each of his ex-girlfriends finds true love with the man she meets after her relationship with him ends. Hearing of Charlie's reputation as a good-luck charm, women from all over line up for a quick tryst. But when Charlie meets the woman (Jessica Alba) of his dreams, he must find a way to break the curse or risk losing her to the next man she meets.
Cursed since childhood, dentist Charlie Kagan (Dane Cook) cannot find the right woman. Even worse, he learns that each of his ex-girlfriends finds true love with the man she meets after her relationship with him ends. Hearing of Charlie's reputation as a good-luck charm, women from all over line up for a quick tryst. But when Charlie meets the woman (Jessica Alba) of his dreams, he must find a way to break the curse or risk losing her to the next man she meets.

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